Similar findings were observed in GL261 tumor-bearing mice showing a significant extension of survival as compared to the radiotherapy treated vehicle control group with 40% of mice showing tumor eradication in combination of radiation+AZD7762 + anti-PD-1 group and 60% of mice showing tumor eradication in combination of radiation+AZD7762 + anti-PD-L1 group (Fig. 9a, b). This evidence concerns the gene PDCD1 and neoplasm.