Specifically, microglial overactivation is an early reaction to the developing pathological change in the CNS, which leads to oxidative damage and the generation of a broad spectrum of pro‐inflammatory cytokines (IL‐1β, IL‐6, TNF‐α, and NF‐κB), and activation of tauopathy‐induced inflammasome NLRP3 pathway [181]. Here, NLRP3 is linked to tauopathy.