SIRT1 and Alzheimer disease: In the animal model of AD, encapsulation of RES‐Se (RES‐selenium) NPs by SLN was successful in the treatment of memory disorder by upregulating the expression of Sirt1 along with PI3K protein and downregulating STAT3 (Signal transducer and transcription activator) expression as well as decrementing the IL‐1β level [168].