AQP4 and myeloid sarcoma: Compared with NMOSD, MS patients have perpendicular lesions to the surface of the lateral ventricles, juxtacortical lesions involving the U or cortical fibers, and peripheral and short spinal cord lesions.1, 41More recently, a hyperintense lesion on spinal MRI (bright spotty lesion) was recognized as a characteristic of AQP4-IgG NMOSD.45