Syncope and presyncope occurred around 4.2% in COVID-19, mainly due to unexplained causes.35As a deficient compensatory heart rate increase was observed in a few patients with syncope during the acute hypocapnic hypoxemia, researchers hypothesize that SARS-CoV-2 could have caused ACE2 internalization in midbrain nuclei changing the baroreflex and chemoreceptor responses.36 This evidence concerns the gene ACE2 and COVID-19.