IL4 and infection: LCM tissue residency is imprinted by mesothelial-cell-derived RA, which maintains GATA6 expression,10 and this has been found to be partially RXR (α and β) dependent.14 MNPs from C57BL/6 mice, regardless of infection status had higher niche-dependent and RXR-dependent gene scores than MNPs from BALB/c mice (Figure S7A), while also having higher M(IL-4) status in infection (Figure S7B), implying that M(IL-4) LCM is an altered cell state that incorporates signals from both the tissue niche and the type 2 response.