A study in vitro showed that BMMSC-CM of rats could improve the proliferation and migration of keratinocytes in a diabetes-like microenvironment by decreasing High Glucose (HG) and/or Lipopolysaccharide (LPS) induced Reactive Oxygen Species (ROS) overproduction and reversing the downregulation of phosphorylation of MEK 1/2 and Erk 1/2.39 Here, MAP2K1 is linked to diabetes mellitus.