In our study, Western blot analysis showed that after over-expression of ADAMTS1 in NSCLC cell lines A549 and H226, the expression of the epithelial marker E-cadherin protein was significantly reduced, while that of the mesenchymal marker N-cadherin and Vimentin protein was significantly increased, indicating that ADAMTS1 could promote the transformation of NSCLC cells from an epithelial cell phenotype to a mesenchymal cell phenotype. The gene discussed is CDH2; the disease is non-small cell lung carcinoma.