The first study on molecular mechanisms underlying CI (Kiang et al. 2010b) showed that radiation followed by skin wounding immensely increased a) inducible nitric oxide synthase (iNOS), b) cytokine/chemokine concentrations in serum, and c) systemic bacterial infection in liver and heart significantly more than radiation alone (Kiang, et al. 2010b; Kiang, et al. 2020). The gene discussed is NOS2; the disease is bacterial infectious disease.