Dysregulated and heightened immune system; prolonged inflammation leading to multiorgan dysfunction; cytokine release syndrome (CRS); Mast Cell Activation Syndrome (MCAS); neutrophil extracellular traps (NETs); pattern recognition receptors (PRRs) including Toll-like receptor (TLR); retinoic acid-inducible gene-I (RIG-I)-like receptors; oxidative stress. This evidence concerns the gene RIGI and congenital rubella syndrome.