NFKB1 and long COVID-19: Some of the potential signaling pathways involved in COVID-19 and PASC pathophysiology involve Toll-like receptors (TLR-3 and TLR-7/8) that recognize SARS-CoV-2 RNA and recruit the inflammatory cascade via type I and II IFN gene expression and NF-κB nuclear translocation (Sabroe et al., 2008; Totura et al., 2015).