IL1B and COVID-19: Whole-transcriptome sequencing of postmortem lung tissue from COVID-19 patients reveals two distinct molecular signatures: Lung damage caused by a massive metabolic reprogramming due to the upregulation of the unfolded protein response, steroid biosynthesis, and complement activation; and secondarily, ‘cytokine release syndrome’ (CRS) represented by the upregulation of cytokines such as IL-1 and CCL19, but absence of complement activation (Budhraja et al., 2022).