A COVID-19-impaired insulin/IGF signaling pathway is also associated with the downregulation of various metabolic pathways including the citrate cycle, lipid metabolism, beta-oxidation, amino acid metabolism, carbohydrate metabolism, and respiratory electron transport chain affecting the adipose tissue, liver, lungs, and pancreas resulting in the development of multiorgan dysfunction (Shin et al., 2022). This evidence concerns the gene INS and COVID-19.