CD8A and lymphoma: To evaluate the OVA‐specific T‐cell response in adult and elderly OT‐I+/− compared to OT‐I+/+ mice, we isolated CD8+ T cells from splenocytes and stimulated them with irradiated E.G7‐OVA mouse lymphoma cells, which constitutively express the H‐2Kb‐restricted OVA257–264 peptide.