Recently, Sapienza et al. (2019) have demonstrated that in Thymidylate synthase, an allosteric MBS homomer that is a major chemotherapeutic target in cancer (Wilson et al. 2014), ligands communicate across the interface, and a small number of “hot-spot” residues are particularly important in transmitting motions between the subunits (Sapienza et al. 2019). This evidence concerns the gene TYMS and cancer.