The top genes with increased expression in HF treatments included PTGDS, GABRA4, and SLC7A3. Of the 173 upregulated genes, there were multiple genes encoding coiled-coil domain containing proteins (CCDC114, CCDC28B, CCDC62, CCDC80,) with genes from this family involved in protein folding [23]. Here, PTGDS is linked to hydrops fetalis.