WDR6 and neoplasm: Among seven representative genes whose levels were significantly upregulated in tumor tissues (Fig 1A and Appendix Table S1), we focused on WDR6 based on three reasons: (i) WDR6 is rarely reported in tumors, and its expression level was higher in our tumor tissue samples (fold change 3.45, P‐value 0.003891); (ii) several members of the WDR family regulate carcinogenesis (Li et al, 2000); (iii) the dysregulation of the six additional genes identified by RNASeq have already been reported to be associated with HCC pathogenesis.