Surprisingly, one study has reported that UVRAG is an activator of the DDB1‐CUL4A‐Roc1 ubiquitin ligase complex by promoting the neddylation and assembly of this E3 ligase complex in DNA damage repair (Yang et al, 2016), indicating an interplay between UVRAG and the CUL4A E3 ligase complex in the tumor‐associated background. The gene discussed is UVRAG; the disease is neoplasm.