Indeed, NF‐κB inhibitor IMD0354 or IκBα‐SR reverted TNFα expression enhanced by WDR6 overexpression (Song et al, 2014) (Fig 5A), indicating that NF‐κB is a critical effector downstream of WDR6 upregulating TNFα secretion in HCC cells. This evidence concerns the gene NFKBIA and hepatocellular carcinoma.