APOE and early-onset autosomal dominant Alzheimer disease: Similarly, APOE‐ε4 non‐carriers in highest quintile of the PRS had a significantly higher probability of Alzheimer's disease than those in the lowest PRS quintile between ages 70 and 85 (difference of 6.7% at age 70 to 30.5% by age 85) (Fig. 2D).