HIF1A and obesity due to melanocortin 4 receptor deficiency: In a colitis mouse model, a lack of HIF-1α in gut DCs exacerbates colitis.72 In obesity mouse models, HIF-1α deficiency in adipose tissue DCs was found to increase adipose tissue inflammation and atherosclerotic plaque formation.73 These studies suggest that selectively activating HIF-1α in DCs could help ease the overreaction of the inflammatory response.