Preclinical studies showed epigenetic and expression changes in glutamate decarboxylase (GAD), reelin and brain-derived neurotrophic factor (BDNF) associated with increased levels of DNA methyltransferases (DNMT) in GABAergic interneurons strongly supporting the hypothesis that schizophrenia represents an “interneuronopathy” in which early onset epigenetic changes in GABAergic interneurons in the frontal cortex cause a disruption in GABAergic/glutamatergic neurotransmission and abnormalities in the oscillation network [35-40]. Here, BDNF is linked to schizophrenia.