Selective ablation of lysine (K) methyltransferase 2a (Kmt2a), a HMT specific for H3K4, which is linked to active transcription, but not the ortholog Kmt2b, in adult ventral striatum/nucleus accumbens neurons, however, markedly increased anxiety-like behavior in multiple behavioral paradigms [127]. The gene discussed is KMT2A; the disease is Anxiety.