HDAC5 and depressive symptom measurement: Further, continuous treatment with the SNRI venlafaxine for 28 consecutive days was observed to prevent an increase in hippocampal HDAC5 expression and subsequent decreases in H3K9ac, H3K14ac and H4K12ac observed after 30 days of chronic unpredicted stress, leading to a significant improvement in anxiety- and depression-like behaviors [97].