HNMT and Anxiety: Vice versa, it was found that knocking down G9a expression in the nucleus accumbens shell led to a decrease in addiction- and anxiety-like behaviors [126], which is in line with pharmacological HMT inhibition by UNC0224 [54] or UNC0642 and A-366 [98] also leading to a reduction in anxiety-like behavior (see 3.3.3).