SIRT6 and Anxiety: Accordingly, chronic bilateral infusion of trichostatin A for seven days – starting at day 8 of 15-day corticosterone stress elicited by the implantation of corticosterone micropellets in the central nucleus of the amygdala - was able to attenuate a number of corticosterone-induced effects such as increased anxiety-like behavior, decreased mechanical somatic sensitivity, a genome-wide downregulation of H3K9ac, increased c-Fos, CRF and SIRT6 expression and decreased glucocorticoid receptor expression [103].