RBM3 and early-onset autosomal dominant Alzheimer disease: This has been observed in scenarios ranging from in vitro protection from forced apoptosis of neuronal cell lines and brain slices (Chip et al, 2011) to profound neuroprotective effects in vivo, where RBM3 induction by cooling or over‐expression restores memory, prevents synapse and neuronal loss, and extends survival in preclinical mouse models of prion and Alzheimer's disease (Peretti et al, 2015, 2021).