Our proteomic analyses have confirmed that MAPK signaling pathway is involved in the pathological process of DCM, and previous studies have shown that ferroptosis could activate the MAPK pathway through ERK1/2 [41, 42], we demonstrated that A-438079 (a specific inhibitor of P2X7) could restrain ERK1/2 signaling pathway, and SPD had the same effect. This evidence concerns the gene MAPK3 and familial dilated cardiomyopathy.