In vivo, western blot results showed that ODC and ACSL-4 expressions were downregulated and SSAT and GPX-4 expressions were upregulated significantly in the T2D group, the opposite trend appeared in the T2D+SPD group, which was consistent with the proteomics results, and then we also observed the same variation tendency in vitro. This evidence concerns the gene ODC1 and Platelet storage pool disease.