PANX1 and type 2 diabetes mellitus: Immunofluorescence results showed that compared with the WT group, the Pannexin-1 fluorescence intensity significantly increased in the T2D group, and significantly decreased in the T2D+SPD group compared to the T2D group (Figure 6A), which was consistent with the trend of western blot and qRT-PCR results (Figure 6B and 6C).