INS and type 2 diabetes mellitus: The results showed that compared with the WT group, the blood glucose levels and glucose intolerance at each time point were higher, the insulin levels were significantly increased, and TG and TC were also increased in the T2D group and T2D+SPD group, Interestingly, compared with T2D group, there were no differences of the above indexes in the T2D+SPD group, also SPD had no effects in the WT group (Figure 1A–1F).