In vivo, western blot results showed that ODC and ACSL-4 expressions were downregulated and SSAT and GPX-4 expressions were upregulated significantly in the T2D group, the opposite trend appeared in the T2D+SPD group, which was consistent with the proteomics results, and then we also observed the same variation tendency in vitro. Here, GPX4 is linked to type 2 diabetes mellitus.