The betel quid chewing can also affect the clinical course of oral cancer under the expression of dipeptidyl peptidase IV SNP rs2268889,36 and the ADAM‐10 also owns the cell migration ability that is similar to dipeptidyl peptidase IV, thus the SNP of ADAM‐10 may show similar effect.16, 37. The gene discussed is DPP4; the disease is lip and oral cavity carcinoma.