About the effect of this ADAM‐10 SNP in other disease, a previous study revealed the correlation between ADAM‐10 SNP rs2305421 G variant and late‐onset Alzheimer's disease,22 and another study also found the possible relationship between the ADAM‐10 SNP rs2305421 G and Alzheimer's disease.34 This evidence concerns the gene ADAM10 and early-onset autosomal dominant Alzheimer disease.