Indeed, PC2‐TRPV4 functional hetero‐tetramers (presumably in 2:2 stoichiometry (Stewart et al., 2010)) have been reported in renal epithelial cells with their activity being compromised in cystic cells of both ADPKD and ARPKD (Tomilin et al., 2018; Zaika et al., 2013; Zhang et al., 2013). This evidence concerns the gene TRPV4 and autosomal dominant polycystic kidney disease.