TRPV4 and autosomal dominant polycystic kidney disease: Currently, we do not have direct experimental evidence showing that pharmacological or dietary (high KCl diet) stimulation of TRPV4 also attenuates the progression of clinically prevalent ADPKD, but it would likely be the case considering the collecting duct origin of the majority of cysts (Bergmann et al., 2018) and similar mechanisms of TRPV4 dysfunction in both PKD types (Tomilin et al., 2018).