Here, we tested how regulation of renal TRPV4 function by dietary K+ intake modulates the rate of cystogenesis and mechanosensitive [Ca2+]i signaling in cystic cells of PCK453 rats, a homologous model of human autosomal recessive PKD (ARPKD). The gene discussed is TRPV4; the disease is autosomal recessive polycystic kidney disease.