We examined the relationship of serum neuro-oxidative stress parameters with stroke severity and infarct volume in ACI and emphasized the qualitative importance of high-density lipoprotein (HDL) on its relationship with myeloperoxidase (MPO) and paraoxonase-1 (PON1) in the acute period of stroke.<h4>Methods</h4>One hundred ACI patients applied within the first 24 h and 50 healthy volunteers were included. The gene discussed is MPO; the disease is Stroke.