Therefore, in order to evaluate the effect of PSA decrease in detecting PCa, we also looked at PCa rates according to PSA change in PI-RADs groups in the current study, in patients who underwent mp-MRI, PCa was observed in 38% (n = 27) of the patients with PSA decrease, and in 37.9% (n = 22) of the patients whose PSA did not change or increased. The gene discussed is KLK3; the disease is posterior cortical atrophy.