In addition to these factors, AF’s being rich in AOx mediators (IGF-1, VEGF, Ang-1) and developmental factors (G-CSF, PIGF, Ang-1, FGF, EGF, PDGF, TGF-α/β) has an important place in its prophylaxis against the harmful factors exposed to in the intrauterine period [18,19]. This evidence concerns the gene EGF and atrial fibrillation.