Furthermore, high AKT3 mRNA expression was associated with a poor OS in patients with lung cancer (HR, 1.31; 95% CI, 1.16–1.49; P=2.2e−05) and patients with LUAD (HR, 2.08; 95% CI, 1.64–2.64; P=7.9e−10), but not in patients with SqCLC (HR, 0.97; 95% CI, 0.77–1.23; P=0.82) (Fig. 1G–I). This evidence concerns the gene AKT3 and lung cancer.