We found that high AKT1 mRNA expression was not significantly associated with OS in patients with lung cancer (hazard ratio [HR], 1.12; 95% confidence interval [CI], 0.99–1.27, P=0.071) or patients with SqCLC (HR, 0.84; 95% CI, 0.67–1.07; P=0.16), but was significantly associated with a poor OS in patients with LUAD (HR, 1.67; 95% CI, 1.31–2.11; P=2.1e−05 (Fig. 1A–C). The gene discussed is AKT1; the disease is lung carcinoma.