In the old age group (OF v OM), there were many more autosomally-encoded DEGs by sex, with markers of disease-associated microglia (21) (i.e., Csf1, Itgax, Cst7) being more highly expressed in old females than old males (as identified in at least one methodology) (Figure 5H–I, K–L). The gene discussed is CST7; the disease is ocular melanoma.