TNFSF12 and central nervous system cancer: Transcriptome analysis of BT25 cells treated with TWEAK or TNFα, which preferentially activate the canonical or noncanonical NF-κB pathways, respectively13,14, revealed that the expression of NIK (MAP3K14) directly correlated with glioma cell invasion and was highly induced in response to TWEAK treatment but not TNFα treatment (Figure 1B, C).