Transcriptome analysis of BT25 cells treated with TWEAK or TNFα, which preferentially activate the canonical or noncanonical NF-κB pathways, respectively13,14, revealed that the expression of NIK (MAP3K14) directly correlated with glioma cell invasion and was highly induced in response to TWEAK treatment but not TNFα treatment (Figure 1B, C). Here, NFKB1 is linked to central nervous system cancer.