Some CoVs accessory proteins functioned as the constitutive component of virions and integrated into virus particles, such as ORF4a of human coronavirus 229E (HCoV-229E),145 3a and 7b of SARS-CoV,78,82 and ORF3 of hCoV-NL63,81 which could explain the essential role that numerous accessory proteins play in viral infection. Here, ASZ1 is linked to viral infectious disease.