While general weight loss during EAE may be attributed to paralysis and reduced food intake, early weight loss prior to paralysis has been reported to be associated with the high production of pro‐inflammatory cytokines, such as TNFα, released during the acute phase of inflammation, causing a loss of appetite (Mardiguian et al., 2013; Tracey et al., 1988). This evidence concerns the gene TNF and Paralysis.