Moreover, a decreased total lymphocytes, prolonged prothrombin time, increased neutrophil count, D‐dimer, blood urea, and creatinine levels were seen in the poor/fair group, suggesting the more severe cellular immune deficiency, direct effects of the virus, cytokine storm, inflammatory response in this cohort, and more severe myocardia, hepatic, and kidney injuries may indicate poor response to COVID‐19 treatment. This evidence concerns the gene F2 and Immunodeficiency.