High-mobility group AT-hook 2 (HMGA2) is a non-histone architectural TF that positively regulates the EMT process in a series of fibrotic diseases (type 2 EMT) and cancer metastasis (type 3 EMT) (Liang et al., 2014; Hou et al., 2018; Zhu et al., 2019; Song et al., 2021; Wang et al., 2021). Here, TF is linked to cancer.