CD4 and obesity due to melanocortin 4 receptor deficiency: Controversial data have been published concerning the effect of T2D and obesity on ASC biological and functional characteristics.4,28-30,35-40 Our research is one of the few studies that addressed the immunoregulatory functions of ASCs from T2D donors.4,28,41 To our knowledge, this is the first study to explore the effects of T2D and obesity on ASCs’ modulatory functions on purified CD4 T cells.