An inflammatory stimulus, such as interferon-gamma (IFN-γ), or crosstalk with active immune cells is necessary for MSCs to exert their immunosuppressive effects.14 Despite the hypoimmunogenic nature of MSCs and the rise of allogeneic MSC therapy,9,26 autologous MSCs may be the relatively safe choice from an immunological point of view.26,27 The inflammation and oxidative stress associated with obesity and T2D may alter the immunophenotype, immunosuppressive functions, and antioxidative properties of ASCs.4,28-30. The gene discussed is IFNG; the disease is obesity due to melanocortin 4 receptor deficiency.