The degree of liver injury and the rate of proinflammatory phenotype acquisition were exacerbated when additional Rm-BMP9 was injected into APAP-ALI model mice and in livers treated with Cebpa-overexpressing AAV2/8 or F4/80-specific Bmp9-overexpressing AAV2/8. This evidence concerns the gene CEBPA and acute respiratory distress syndrome.