So far, the role of EFEMP2 in tumorigenesis is found to be “context-specific”; indeed, while in cervical cancer, ovarian cancer, and glioblastoma it has been associated with tumor progression and poor prognosis, in endometrial cancer it has been found to inhibit EMT, tumor invasion and metastasis [72]. The gene discussed is EFEMP2; the disease is glioblastoma.