Another study induced chronic, tumor-promoting allergic contact dermatitis (ACD) in 6- to 8-week-old mice by treating them with 1-fluoro-2,4-dinitrobenzene (DNFB) and found that IL-33 expression was key in inducing the transition from acute, tumor-suppressing inflammation to chronic inflammation [271]. Here, IL33 is linked to granular corneal dystrophy type II.