ADNP and Alzheimer disease: Interestingly, somatic ADNP mutations are directly correlated with increased tauopathy in the AD brain [85] and tauopathy was discovered in postmortem HVDAS child brain [86] as well as in mouse models with either Adnp haploinsufficiency [13] or carrying the p.Tyr718* mutation (the human p.Tyr719* orthologue [52]).