Thus, excessive ROS production in tumor tissues is currently a popular strategy for tumor treatment, such as enzyme-catalyzed therapy (ROS-producing enzyme or enzyme complex, peroxidase, glucose oxidase (GOx), etc. Huo et al. prepared mesoporous silica loaded with GOx and Fe3O4 and formed GOx-Fe3O4@DMSN. The gene discussed is HAO1; the disease is neoplasm.