Our results showed that inhibiting HIF-1α/NLRP3 signaling resolved the MDA/SOD imbalance after thalamic hemorrhagic stroke, which was corroborated by previous studies showing that HIF-1α and NLRP3 inflammasome activation increases brain oxidative stress after cerebral ischemia in rats [51, 52]. Here, SOD1 is linked to hemorrhagic stroke.