The main marker genes are AQP8 [25], CA7 [26], MS4A12 [27], LRMP [28], LCN2 [29], and PI3 [30], BEST4, SH2D6 (no report is available about BEST4, SH2D6 and colon cancer). The gene discussed is SH2D6; the disease is malignant colon neoplasm.