In C2 goblet cells, during the process from normal colon to adenoma and from adenoma to carcinoma, several continuously highly expressed genes were found, including DEFA6 [14], SOX9 [15, 16], ID1 [17], L1TD1 [18], CXCL3 [19], and ODC1 [20]. The gene discussed is L1TD1; the disease is adenoma.