And the 6 coincident genes significantly enriched in adenoma and carcinoma were DEFA6 [14], SOX9 [15, 16], ID1 [17], L1TD1 [18], CXCL3 [19], and ODC1 [20] (Additional file 1: Fig.S1C, S1D). This evidence concerns the gene CXCL3 and adenoma.