GDF15 and colonic neoplasm: In addition, evidence of involvement in carcinogenesis was found,some of them function as oncogenes in colon cancer including LCN2 [29], DUOX2 [33], CEACAM6 [34], CD55 [35], MUC5B [36], TM4SF1 [37], REG4 [38], TFF1 [39], GDF15 [40], and ANXA2 [41].