Researchers have shown that ARDS subphenotypes can be accurately identified with parsimonious classifier models using three (interleukin [IL]-8, bicarbonate, and protein C) or four variables (IL-8, bicarbonate, protein C, and vasopressin use), thereby facilitating the identification of ARDS phenotypes for use in clinical trials and practice [14]. Here, CXCL8 is linked to acute respiratory distress syndrome.