PNPLA3 and steatosis: The increase of HOMA2-IR occurred in parallel with the increase of HTGC in those with the PNPLA3 rs738409 GG risk genotype and partially behaves like a biomarker of intrahepatic steatosis that is dissociated from the other surrogate marker of IR, the TyG index composed of only metabolic parameters but does not directly include serum insulin level.