Although prior studies with human liver tissue samples reported that the hepatic content of diacylglycerol (DAG) species (FA18:1, implicated in diminished insulin signaling) remained unaltered in rs738409 homozygous and heterozygous G allele carriers (M148M and I148M) and it was hypothetically suggested that the G risk allele carriers might be protected from insulin resistance [45] we report here that the HOMA2-IR values remained correlated with HTGC. Here, INS is linked to Insulin resistance.