Previous studies have showed that the transcription factors NF-κB, PU.1 and ATF2 are associated with the modulation of the TREM-1 gene transcription6,11, however, to date, no study has investigated the association of these transcription factors with TREM-1 gene transcription in conditions of low ESS in an atherosclerosis-relevant model. This evidence concerns the gene NFKB1 and atherosclerosis.