Previous studies have reported that suppression of TREM-1 by RNA interference significantly impaired the inflammatory response to oxidized LDL in macrophages12, and that genetic deletion (trem-1 knockout mice) or pharmacological inhibition (LR12 peptide) of TREM-1 significantly reduced the development of atherosclerosis throughout the vascular tree and lessened plaque inflammation in mice13. This evidence concerns the gene TREM1 and atherosclerosis.