Consistent with the two recently reported enhancer landscapes of bladder cancer [27, 28], Luminal-activated SE were located in proximity to known key regulators of the Luminal phenotype, namely FOXA1, GATA3, and PPARG [3, 14, 28], and to new Luminal-associated genes, such as NPAS2 and GRHL2 – also identified by Iyyanki et al. [27] – or KLF5, recently characterized as activated through super-enhancer amplification in various squamous cell carcinomas [43]. The gene discussed is GRHL2; the disease is squamous cell carcinoma.