FOXA1 and cancer: Notably, FOXA1 knock-down induced upregulation of master interferon response TFs, STAT1 and STAT2, and key genes involved in the regulation of inflammation in human cancer, including the immune checkpoint modulator CD274 (PD-L1) (Fig. 6D), which we also identified as a downregulated SE in both Luminal and Basal vs NHU cells (see earlier Fig. 3F).