This strategy identified a large module of Luminal TFs, including known Luminal-associated TFs (e.g., FOXA1/GATA3/PPARG), as well as TFs with yet unexplored roles in Luminal bladder cancer biology (e.g., HES1, FOXQ1, ZBTB7C, MECOM, GRHL2/3, and TBX3). Here, GRHL2 is linked to urinary bladder cancer.