To determine if FOXA1, through its binding to the SE repertoire, regulates the bladder cancer epigenetic landscape and subsequently cellular identity, we produced FOXA1 CRISPR mutant clones allowing long-term FOXA1 inactivation in two Luminal cell lines (SD48 and RT112, Fig. S7G). This evidence concerns the gene FOXA1 and urinary bladder carcinoma.