The proportion of CD4 T cells was indicated by a significant decrease in the subjects from baseline to d7 (Fig. 3a) and the inverted CD4/CD8 ratio (Fig. 3b), which was also reported in other high-altitude populations33, reminding us of the enhanced immunity and susceptibility to sAMS. Here, CD8A is linked to short stature-auditory canal atresia-mandibular hypoplasia-skeletal anomalies syndrome.