We noticed that both hsa-miR-133a-3p and hsa-miR-133b-3p mediate the signals from SLC8A2 or DIP2B to SLC4A1, a biomarker of AMS, which was correlated with various AMS symptoms and plays important roles in CO2 gas transport in erythrocytes44. Here, SLC8A2 is linked to ablepharon macrostomia syndrome.