Meanwhile, as the potential risk factors of sAMS, the CD4/CD8 ratio, the estimated proportion of T cells, SaO2, P50, hemoglobin, and CaO2 were indicated with significant correlations with the LLQ-AMS score (Pearson correlation test, P < 0.001). Here, CD8A is linked to short stature-auditory canal atresia-mandibular hypoplasia-skeletal anomalies syndrome.