To further identify function modules among the 2286 DGs and the relationship to the risk factors of sAMS, weighted correlation network analysis (WGCNA)27 was performed using the values of PaO2, PaCO2, SaO2, CaO2, P50, hemoglobin, LLQ-AMS score, AMS-C-composite score, CD4/CD8 ratio, and the estimated proportion of T cells as a trait. The gene discussed is CD8A; the disease is short stature-auditory canal atresia-mandibular hypoplasia-skeletal anomalies syndrome.