Then, the CD4/CD8 ratio, SaO2, CaO2, P50, hemoglobulin, and the estimated proportion of T cells were further investigated for the interplay effects between them, aiming to identify the underlying risk genes of sAMS (Fig. 3c,d). The gene discussed is CD8A; the disease is short stature-auditory canal atresia-mandibular hypoplasia-skeletal anomalies syndrome.