As shown in Table 1, we identified 37 studies that tested the effects of pharmacological (25 studies) and genetic (12 studies) manipulation of TRAF2 (9 studies), TRAF4 (14 studies) or TRAF6 (15 studies) on tumour weight/volume (28 studies) and metastasis to the lung (3 studies), skeleton (4 studies) and liver (1 studies) in rodents bearing human (28 studies: MDA-MB-231, 22 studies and MCF-7, 6 studies) or mouse 4T1 (9 studies) breast cancer cells. The gene discussed is TRAF4; the disease is breast cancer.