TRAF6 and neoplasm: As shown in Fig. 2 (panels A and B), our investigation shows that TRAF6 as well as TRAF4 genes are highly amplified in samples from metastatic breast cancer patients (TRAF6: 9.3% and TRAF4: 27.8%) when compared primary tumours (TRAF6: 7.2% and TRAF4: 21.7%).