In animal models of BCa, administration of pharmacological inhibitors of TRAF2/4 (Std.MD: − 3.36, 95% CI: − 4.53, − 2.18, P < 0.00001) or TRAF6 (Std.MD: − 4.15, 95% CI: − 6.06, − 2.24, P < 0.0001) in mice is associated with reduction in tumour burden. The gene discussed is TRAF6; the disease is neoplasm.