TRAF4 and breast carcinoma: mean difference − 4.15, 95% CI − 6.06, − 2.24, Z score 4.25 (P < 0.0001)) is associated with significant reduction in tumour weight and volume in female rodents bearing the human triple-negative MDA-MB-231 (TRAF2, TRAF4 and TRAF6) and mouse 4T1 (TRAF6) breast cancer cells (Table 3).