ITGAX and cancer: Tumor-infiltrating immune cells represent the actual conditions of the tumor immune microenvironment. The immune cells such as macrophages (CD11c+ and F4/80+) were reduced in the ineffective group in comparison to the effective group, indicating that Ce6-PDT was unable to promote the sufficient release of tumor antigens (B16F10 and Panc02), which could not activate immune cells and further kill cancer cells.