The linear mixed model analysis revealed a time-dependent increase in between-group differences in TBW/H2, although this difference was not significant (p = 0.074) after adjusting for confounding factors of age, sex, age-modified CCI, history of diabetes mellitus, hypertension, SOFA score, urine output for 6 h, serum albumin, and the Modification of Diet in Renal Disease equation, which estimates the glomerular filtration rate at CRRT initiation. The gene discussed is ALB; the disease is diabetes mellitus.