CCDC136 and hypertrophic cardiomyopathy: Using Hi-C analysis, we observed several potentially relevant chromatin interactions, including between lead variant rs56252725 on chromosome 16 and gene MYH11, which encodes an isoform of the myosin heavy chain which is highly expressed in LV tissue and has been associated with electrocardiogram amplitude, and between lead variant rs143973349 (European-only analysis) and gene CCDC136, which encodes a membrane protein and in which variants have been previously associated with dilated and hypertrophic cardiomyopathies.