The remaining loci (n = 11) were novel, with many located at or proximate to genes implicated in arrhythmias, cardiomyopathy and cardiomyocyte function, including FLNC, MYOZ1, MAPT, WNT, CLCN6, MYBPC3 and SYNPO2L. Regional association plots for each genome-wide significant SNP are shown in Supplementary Fig. 2. This evidence concerns the gene SYNPO2L and cardiac arrhythmia.