In erastin- or RSL3-induced ferroptosis of HCC cells, IFN-γ triggered the JAK-STAT-IRF1 signaling pathway and suppressed the transcription of system Xc- subunits solute carrier family 3 member 2 (SLC3A2) and SLC7A11 [52]. This evidence concerns the gene SOAT1 and hepatocellular carcinoma.