Then, we explored the function of integrin β3 (ITGB3) in human T-ALL cell lines, Jurkat and MOLT-4 by determining the affect of ITGB3 inhibitors or ITGB3 RNA interference on the cell malignancy behavior and phosphorylation of downstream signal transducer of integrin, FAK-MAPK axis. Here, ITGB3 is linked to acute lymphoblastic leukemia.