FLT3 and acute myeloid leukemia: Although integrin β3 was identified as an inducer of invasion or metastasis in solid tumors [10,39,40], study by Yi et al. [32] showed that integrin αvβ3 antagonized tyrosine kinase inhibitor (TKI) activity of sorafenib in patients with Fms-related tyrosine kinase 3 (Flt3) mutated AML.